Single Compound vs. Whole Plant CBD
Single Compound CBD is just isolated CBD, meaning it only contains CBD and not other terpenes or cannabinoids. On the flip side Whole Plant CBD is derived using the entire plant and gives you all of the terpenes and other cannabinoids found in cannabis.
Whole Plant CBD is the more effective type of CBD because of the Entourage Effect and terpenes. See our article on the Entourage Effect for more information.
A clinical study done in 2015 documented the superior therapeutic properties of whole plant CBD-rich cannabis extract, as compared to single-molecule cannabidiol (CBD).
The study was published in the journal of Pharmacology & Pharmacy (Feb. 2015) and was titled “Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol.”
These studies showed that administration of pure, single-molecule CBD resulted in a bell-shaped dose-response curve, meaning that when the amount of CBD exceeded a certain point, its therapeutic impact declined dramatically. This characteristic of single-molecule CBD manifested as a bell-shaped dose response, imposes serious obstacles that limit its usefulness in a medicinal context.
When Scientists then administered whole plant CBD, they found that there was no bell shaped curve and that there was a clear correlation between the dosage administered and its effects. They also found that it took a significantly less amount of whole plant CBD then it did CBD isolate to get the same anti-inflammatory and anti-nausea effects.
If you’re interested in reading the entire study the link is provided here.